PD-1 And PD-L1 Inhibitors Market By Type (PD-1, PD-L1), By Application (Hodgkin Lymphoma, Kidney Cancer, Melanoma, Non-small Cell Lung Cancer), By Distribution Channel (Hospitals, Retail Pharmacies, Online Pharmacies), & Region for 2024– 2031
Report ID: 11130|No. of Pages: 202
PD-1 And PD-L1 Inhibitors Market By Type (PD-1, PD-L1), By Application (Hodgkin Lymphoma, Kidney Cancer, Melanoma, Non-small Cell Lung Cancer), By Distribution Channel (Hospitals, Retail Pharmacies, Online Pharmacies), & Region for 2024– 2031
PD-1 And PD-L1 Inhibitors Market Valuation – 2024-2031
The increasing need for immunotherapy to treat highly prevalent disease, especially cancer, are important drivers of the PD-1 And PD-L1 Inhibitors Market. According to the analyst from Verified Market Research, the PD-1 And PD-L1 Inhibitors Market is estimated to reach a valuation of USD 137.53 Billion over the forecast period 2031, by subjugating around USD 39.86 Billion valued in 2023.
The shift to personalized medicine, as well as the growing trend of combination therapy in which PD-1 and PD-L1 inhibitors are used in conjunction with other medicines, are helping to drive market growth. It enables the market to grow at a CAGR of 16.75% from 2024 to 2031.
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PD-1 And PD-L1 Inhibitors Market: Definition/Overview
PD-1 and PD-L1 inhibitors are a type of drug that works by inhibiting particular proteins in the body’s immune system, specifically programmed cell death protein 1 (PD-1) and programmed death-ligand 1. These proteins serve an important role in inhibiting the immunological response to cancer cells, allowing tumors to avoid identification and elimination by the immune system. These drugs work by blocking PD-1 or PD-L1, allowing the immune system to recognize and destroy cancer cells, thus increasing the body’s natural defenses against cancer.
Furthermore, PD-1 and PD-L1 inhibitors have demonstrated great efficacy in the treatment of a variety of cancers, including melanoma, lung cancer, bladder cancer, and others. They are frequently used alone or in conjunction with other cancer medicines, such as chemotherapy or targeted therapy, and have changed the face of cancer treatment by providing new hope to patients with advanced or metastatic disease.
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How will Rise in Cancer Profit the PD-1 And PD-L1 Inhibitors Market?
The global growth in cancer incidence rates is increasing the demand for effective cancer medicines, such as PD-1 and PD-L1 inhibitors. These inhibitors have shown promising effects in the treatment of many cancers by improving the immune system’s ability to kill cancer cells. The need for novel and potent therapies like PD-1 and PD-L1 inhibitors is only going to increase because cancer is still one of the major causes of mortality globally.
Immunotherapy has advanced significantly in recent years, with PD-1 and PD-L1 inhibitors leading the way. These medications have transformed cancer treatment, providing new hope to patients with previously incurable types of the illness. Continuous research & development in this domain is resulting in greater knowledge, superior medication formulations, and broader indications for these inhibitors, accelerating market expansion.
Furthermore, the PD-1 And PD-L1 Inhibitors Market is fueled by a large pipeline of pharmaceuticals in various phases of clinical development, as well as regular regulatory approvals for new indications and medications. Regulatory organizations such as the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have approved several PD-1 and PD-L1 inhibitors for various cancers. This regulatory support is permitting these medications’ quick market access, broadening their use across numerous indications and contributing to market expansion.
Will Side Effects of the PD-1 And PD-L1 Inhibitors Challenge the Expansion of Market?
These treatments stimulate the immune system to attack normal organs and tissues in the body, which can result in serious or even fatal side effects. Managing immune-related adverse events is a substantial problem for healthcare professionals because it demands careful patient monitoring, early management, and, in some cases, medication withdrawal, all of which have an impact on market growth.
PD-1 and PD-L1 inhibitors are among the most expensive cancer treatments on the market. Their high-cost limits patient access, particularly in low- and middle-income countries or with insurance coverage that may not completely cover these treatments. The financial burden that these therapies impose on healthcare systems and patients is enormous, prompting initiatives to enhance affordability and accessibility.
Furthermore, not all patients react to PD-1/PD-L1 inhibitors, and those who do may develop resistance to these treatments. The variety of response rates makes it difficult to identify the best candidates for these treatments. Also, identifying and overcoming resistance mechanisms to improve long-term outcomes is a significant area of research and development, impacting its market demand.
Category-wise Acumens
What Factors Boost the Demand for the PD-1 type Segment?
According to VMR analyst, the PD-1 segment is expected to dominate the segment within the PD-1 And PD-L1 Inhibitors Market. PD-1 inhibitors have been approved for a broader spectrum of cancer types than PD-L1 inhibitors. Drugs such as nivolumab (Opdivo) and pembrolizumab (Keytruda) have been approved for a variety of indications, including melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma, head and neck cancer, and more. This wide range of approvals has considerably helped their increased market share because they can serve a broader patient population.
PD-1 inhibitors have shown great efficacy in improving survival rates in a variety of malignancies. Their ability to more effectively activate the immune system in some situations is resulting in long-lasting responses in a fraction of patients. This excellent clinical efficacy is aiding in rapid adoption among oncologists as well as securing a dominant commercial position.
Furthermore, there has been a strategic emphasis on developing PD-1 inhibitors in combination with other treatments such as CTLA-4 inhibitors, chemotherapy, targeted therapy, and radiation. These combinations have frequently demonstrated improved efficacy in clinical trials, leading to more approvals and increased use. Such initiatives have helped PD-1 inhibitors solidify their place in the oncology therapeutic landscape and sustain market dominance.
How does the High Incidence of Non-small Cell Lung Cancer (NSCLC) Impact the Market?
The non-small cell lung cancer (NSCLC) segment is estimated to hold the largest share of the PD-1 And PD-L1 Inhibitors Market during the forecast period. NSCLC is the most prevalent kind of lung cancer, accounting for around 85% of all occurrences. NSCLC’s high incidence and prevalence worldwide make it a main target for PD-1/PD-L1 therapies. Because lung cancer is one of the major causes of cancer-related deaths worldwide, there is a strong demand for effective therapies, which contributes to the huge market share for NSCLC applications.
There is strong clinical evidence demonstrating the efficacy of PD-1/PD-L1 inhibitors in treating NSCLC, and these medications have received multiple regulatory approvals in this indication. These inhibitors’ success in improving survival rates, as well as their favourable safety profile when compared to standard chemotherapies, have made them the primary treatment option for NSCLC, contributing to their market dominance.
Furthermore, PD-1/PD-L1 inhibitors are progressively being included in national and international therapy guidelines for NSCLC. Their importance in both first-line and later lines of therapy for NSCLC has grown, thanks to continuous research and favorable clinical trial results. This growing popularity by healthcare experts and recommendations in treatment protocols is contributing greatly to NSCLC’s dominant market position in the PD-1/PD-L1 inhibitors market.
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Country/Region-wise Acumens
How will the Demand for PD-1 and PD-L1 in North America Influence the Market?
North America region is estimated to dominate the market during the forecast period. North America, particularly the United States, has one of the world’s most advanced healthcare infrastructures, along with high healthcare spending per capita. This provides universal access to cutting-edge cancer medicines, such as PD-1 and PD-L1 inhibitors. The healthcare system’s desire and ability to spend on pricey, novel cures plays a crucial role in the region’s market dominance.
Furthermore, Non-small cell lung cancer (NSCLC), melanoma, and renal cell carcinoma are all common in North America and can be treated with PD-1 and PD-L1 inhibitors. Furthermore, as the population becomes more aware of cancer screening and diagnostics, tumors are more frequently discovered at stages where sophisticated therapies can be used, increasing demand for PD-1/PD-L1 inhibitors.
Will Ongoing Research in Oncology Favor the Market in the Asia Pacific?
Asia-Pacific is emerging as a hotspot for oncology research and clinical trials, thanks in part to the vast patient populations available for study recruitment. Pharmaceutical companies are increasingly conducting clinical trials in the region, not only to speed up medication development but also to customize treatments to the genetic and environmental peculiarities of local populations. This emphasis on research & development is accelerating the approval and use of PD-1/PD-L1 inhibitors in the area, adding to market growth.
Furthermore, cancer incidence in the Asia Pacific region has risen dramatically, owing to causes such as ageing populations, lifestyle changes, and environmental variables. Countries such as China and Japan have a large number of cancer patients, especially lung cancer and melanoma, which are highly susceptible to PD-1 and PD-L1 inhibitors. This rising prevalence is driving up demand for effective cancer treatments, such as PD-1/PD-L1 inhibitors.
Competitive Landscape
The PD-1 And PD-L1 Inhibitors Market is characterized by fierce competition and rapid development as a result of continuing research, clinical studies, and regulatory approval. In addition, the emergence of biosimilars and next-generation medicines increases competition, forcing incumbents to strengthen their market positions through strong intellectual property strategies and aggressive pricing methods.
Some of the prominent players operating in the PD-1 And PD-L1 Inhibitors Market include:
AbbVie Inc., Amgen Inc., AstraZeneca Plc, Bristol-Myers Squibb Company, Hoffmann-La Roche Ltd., Merck & Co., Inc., Incyte Corporation, EMD Serono, Inc., BeiGene, Ltd., Eli Lilly and Company, GlaxoSmithKline Plc, Innovent Biopharmaceuticals, Inc., Jiangsu Hengrui Medicine Co., Ltd., Jounce Therapeutics, Inc., Merck KGaA, Regeneron Pharmaceuticals Inc., Seagen Inc., Shanghai Junshi Biosciences Co., Ltd., Sino Biopharmaceutical Limited, Zai Lab Limited.
Latest Developments:
- In February 2024, BMS and Checkmate Pharmaceuticals announced a collaboration to explore next-generation PD-1 inhibitors for solid tumours.
- In February 2024, BeiGene presented favourable results from a clinical trial assessing tislelizumab (PD-1 inhibitor) in combination with chemotherapy for first-line treatment of esophageal squamous cell carcinoma at the American Society of Clinical Oncology’s (ASCO) Gastrointestinal Cancers Symposium.
- In February 2024, Merck announced encouraging findings from the Phase III KEYNOTE-918 trial that evaluated pembrolizumab (PD-1 inhibitor) for the treatment of high-risk, early-stage oesophagus or gastroesophageal junction (GEJ) adenocarcinoma.
Report Scope
| Report Attributes | Details |
|---|---|
| Study Period | 2018-2031 |
| Growth Rate | CAGR of ~16.75% from 2024 to 2031 |
| Base Year for Valuation | 2023 |
| Historical Period | 2018-2022 |
| Forecast Period | 2024-2031 |
| Quantitative Units | Value in USD Billion |
| Report Coverage | Historical and Forecast Revenue Forecast, Historical and Forecast Volume, Growth Factors, Trends, Competitive Landscape, Key Players, Segmentation Analysis |
| Segments Covered |
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| Regions Covered |
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| Key Players |
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| Customization | Report customization along with purchase available upon request |
PD-1 And PD-L1 Inhibitors Market, By Category
Type:
- PD-1
- PD-L1
Application:
- Hodgkin Lymphoma
- Kidney Cancer
- Melanoma
- Non-small Cell Lung Cancer
- Others
Distribution Channel:
- Hospitals
- Retail Pharmacies
- Online Pharmacies
Region:
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
Research Methodology of Verified Market Research:
To know more about the Research Methodology and other aspects of the research study, kindly Get in touch with our sales team.
Reasons to Purchase this Report
• Qualitative and quantitative analysis of the market based on segmentation involving both economic as well as non-economic factors
• Provision of market value (USD Billion) data for each segment and sub-segment
• Indicates the region and segment that is expected to witness the fastest growth as well as to dominate the market
• Analysis by geography highlighting the consumption of the product/service in the region as well as indicating the factors that are affecting the market within each region
• Competitive landscape which incorporates the market ranking of the major players, along with new service/product launches, partnerships, business expansions, and acquisitions in the past five years of companies profiled
• Extensive company profiles comprising of company overview, company insights, product benchmarking, and SWOT analysis for the major market players
• The current as well as the future market outlook of the industry with respect to recent developments (which involve growth opportunities and drivers as well as challenges and restraints of both emerging as well as developed regions
• Includes in-depth analysis of the market of various perspectives through Porter’s five forces analysis
• Provides insight into the market through Value Chain
• Market dynamics scenario, along with growth opportunities of the market in the years to come
• 6-month post-sales analyst support
Customization of the Report
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Frequently Asked Questions
1 INTRODUCTION OF GLOBAL PD-1 AND PD-L1 INHIBITORS MARKET
1.1 Overview of the Market
1.2 Scope of Report
1.3 Assumptions
2 EXECUTIVE SUMMARY
3 RESEARCH METHODOLOGY OF VERIFIED MARKET RESEARCH
3.1 Data Mining
3.2 Validation
3.3 Primary Interviews
3.4 List of Data Sources
4 GLOBAL PD-1 AND PD-L1 INHIBITORS MARKET OUTLOOK
4.1 Overview
4.2 Market Dynamics
4.2.1 Drivers
4.2.2 Restraints
4.2.3 Opportunities
4.3 Porters Five Force Model
5 GLOBAL PD-1 AND PD-L1 INHIBITORS MARKET, BY TYPE
5.1 Overview
5.2 PD-1
5.3 PD-L1
6 GLOBAL PD-1 AND PD-L1 INHIBITORS MARKET, BY APPLICATION
6.1 Overview
6.2 Hodgkin Lymphoma
6.3 Kidney Cancer
6.4 Melanoma
6.5 Non-small Cell Lung Cancer
6.6 Others
7 GLOBAL PD-1 AND PD-L1 INHIBITORS MARKET, BY DISTRIBUTION CHANNEL
7.1 Overview
7.2 Hospitals
7.3 Retail Pharmacies
7.4 Online Pharmacies
8 GLOBAL PD-1 AND PD-L1 INHIBITORS MARKET, BY GEOGRAPHY
8.1 Overview
8.2 North America
8.2.1 U.S.
8.2.2 Canada
8.2.3 Mexico
8.3 Europe
8.3.1 Germany
8.3.2 U.K.
8.3.3 France
8.3.4 Rest of Europe
8.4 Asia Pacific
8.4.1 China
8.4.2 Japan
8.4.3 India
8.4.4 Rest of Asia Pacific
8.5 Rest of the World
8.5.1 Latin America
8.5.2 Middle East & Africa
9 GLOBAL PD-1 AND PD-L1 INHIBITORS MARKET COMPETITIVE LANDSCAPE
9.1 Overview
9.2 Company Market Ranking
9.3 Key Development Strategies
10 COMPANY PROFILES
10.1 AbbVie Inc.
10.1.1 Overview
10.1.2 Financial Performance
10.1.3 Product Outlook
10.1.4 Key Developments
10.2 Amgen Inc.
10.2.1 Overview
10.2.2 Financial Performance
10.2.3 Product Outlook
10.2.4 Key Developments
10.3 AstraZeneca Plc
10.3.1 Overview
10.3.2 Financial Performance
10.3.3 Product Outlook
10.3.4 Key Developments
10.4 Bristol-Myers Squibb Company
10.4.1 Overview
10.4.2 Financial Performance
10.4.3 Product Outlook
10.4.4 Key Developments
10.5 F. Hoffmann-La Roche Ltd.
10.5.1 Overview
10.5.2 Financial Performance
10.5.3 Product Outlook
10.5.4 Key Developments
10.6 Merck & Co., Inc.
10.6.1 Overview
10.6.2 Financial Performance
10.6.3 Product Outlook
10.6.4 Key Developments
10.7 Incyte Corporation
10.7.1 Overview
10.7.2 Financial Performance
10.7.3 Product Outlook
10.7.4 Key Developments
10.8 EMD Serono, Inc.
10.8.1 Overview
10.8.2 Financial Performance
10.8.3 Product Outlook
10.8.4 Key Developments
10.9 BeiGene, Ltd.
10.9.1 Overview
10.9.2 Financial Performance
10.9.3 Product Outlook
10.9.4 Key Developments
10.10 Eli Lilly and Company
10.10.1 Overview
10.10.2 Financial Performance
10.10.3 Product Outlook
10.10.4 Key Developments
11 Appendix
11.1 Related Research
Report Research Methodology
Verified Market Research uses the latest researching tools to offer accurate data insights. Our experts deliver the best research reports that have revenue generating recommendations. Analysts carry out extensive research using both top-down and bottom up methods. This helps in exploring the market from different dimensions.
This additionally supports the market researchers in segmenting different segments of the market for analysing them individually.
We appoint data triangulation strategies to explore different areas of the market. This way, we ensure that all our clients get reliable insights associated with the market. Different elements of research methodology appointed by our experts include:
Exploratory data mining
Market is filled with data. All the data is collected in raw format that undergoes a strict filtering system to ensure that only the required data is left behind. The leftover data is properly validated and its authenticity (of source) is checked before using it further. We also collect and mix the data from our previous market research reports.
All the previous reports are stored in our large in-house data repository. Also, the experts gather reliable information from the paid databases.
For understanding the entire market landscape, we need to get details about the past and ongoing trends also. To achieve this, we collect data from different members of the market (distributors and suppliers) along with government websites.
Last piece of the ‘market research’ puzzle is done by going through the data collected from questionnaires, journals and surveys. VMR analysts also give emphasis to different industry dynamics such as market drivers, restraints and monetary trends. As a result, the final set of collected data is a combination of different forms of raw statistics. All of this data is carved into usable information by putting it through authentication procedures and by using best in-class cross-validation techniques.
Data Collection Matrix
| Perspective | Primary Research | Secondary Research |
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Econometrics and data visualization model
Our analysts offer market evaluations and forecasts using the industry-first simulation models. They utilize the BI-enabled dashboard to deliver real-time market statistics. With the help of embedded analytics, the clients can get details associated with brand analysis. They can also use the online reporting software to understand the different key performance indicators.
All the research models are customized to the prerequisites shared by the global clients.
The collected data includes market dynamics, technology landscape, application development and pricing trends. All of this is fed to the research model which then churns out the relevant data for market study.
Our market research experts offer both short-term (econometric models) and long-term analysis (technology market model) of the market in the same report. This way, the clients can achieve all their goals along with jumping on the emerging opportunities. Technological advancements, new product launches and money flow of the market is compared in different cases to showcase their impacts over the forecasted period.
Analysts use correlation, regression and time series analysis to deliver reliable business insights. Our experienced team of professionals diffuse the technology landscape, regulatory frameworks, economic outlook and business principles to share the details of external factors on the market under investigation.
Different demographics are analyzed individually to give appropriate details about the market. After this, all the region-wise data is joined together to serve the clients with glo-cal perspective. We ensure that all the data is accurate and all the actionable recommendations can be achieved in record time. We work with our clients in every step of the work, from exploring the market to implementing business plans. We largely focus on the following parameters for forecasting about the market under lens:
- Market drivers and restraints, along with their current and expected impact
- Raw material scenario and supply v/s price trends
- Regulatory scenario and expected developments
- Current capacity and expected capacity additions up to 2027
We assign different weights to the above parameters. This way, we are empowered to quantify their impact on the market’s momentum. Further, it helps us in delivering the evidence related to market growth rates.
Primary validation
The last step of the report making revolves around forecasting of the market. Exhaustive interviews of the industry experts and decision makers of the esteemed organizations are taken to validate the findings of our experts.
The assumptions that are made to obtain the statistics and data elements are cross-checked by interviewing managers over F2F discussions as well as over phone calls.
Different members of the market’s value chain such as suppliers, distributors, vendors and end consumers are also approached to deliver an unbiased market picture. All the interviews are conducted across the globe. There is no language barrier due to our experienced and multi-lingual team of professionals. Interviews have the capability to offer critical insights about the market. Current business scenarios and future market expectations escalate the quality of our five-star rated market research reports. Our highly trained team use the primary research with Key Industry Participants (KIPs) for validating the market forecasts:
- Established market players
- Raw data suppliers
- Network participants such as distributors
- End consumers
The aims of doing primary research are:
- Verifying the collected data in terms of accuracy and reliability.
- To understand the ongoing market trends and to foresee the future market growth patterns.
Industry Analysis Matrix
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